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Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein

✍ Scribed by Agnieszka K. Olejnik-Schmidt; Marcin T. Schmidt; Anna Goździcka-Józefiak

Book ID: 111490302
Publisher: SP Versita
Year: 2006
Tongue: English
Weight: 435 KB
Volume: 11
Category: Article
ISSN: 1425-8153
DOI: 10.2478/s11658-006-0010-x

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✦ Synopsis

Abstract

The human NR4A1 orphan receptor is a member of the TR3 steroid receptor superfamily, which binds DNA at the NBRE and NurRE responsive elements. The TR3 receptors are involved in the regulation of differentiation, proliferation and apoptosis. We report that NR4A1 interacts with human papillomavirus type 16 (HPV16) E2 protein — a key papillomavirus regulatory factor. This interaction might be involved in the transcription regulation of the HPV16 genes and the regulation of infected cell homeostasis.

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