Orotate complexes. Synthesis and crystal structure of lithium orotate(—I) monohydrate and magnesium bis[ orotate(—I)] octahydrate

✍ Scribed by Bach, Ina ;Kumberger, Otto ;Schmidbaur, Hubert

• Book ID: 101816351
• Publisher: Wiley (John Wiley & Sons)
• Year: 1990
• Tongue: English
• Weight: 487 KB
• Volume: 123
• Category: Article
• ISSN: 0009-2940
• DOI: 10.1002/cber.19901231207

✦ Synopsis

Magnesium complexes / Lithium complexes / Magnesium therapy Neutralization of orotic acid (OrH,) by lithium or magnesium hydroxide in aqueous medium yields the crystalline metal orotate hydrates Li(OrH) . H 2 0 (1) and Mg(OrH), . (H,O), (2). By single-crystal X-ray diffraction studies it has been shown that 1 (space group P1) forms a layer structure, with lithium in a tetrahedral environment of oxygen atoms from three different orotate( -I) anions (one carboxylate and two uracil oxygen atoms) and the water molecule. 2 (space group P2,/c) has been shown to feature a hexaquo complex of magnesium, the Mg(H,O);@ cations being associated with two hydrated OrHe ions only through hydrogen bonds. The anions are also engaged in "base-pairing'' hydrogen bonds between the planar uracil ring systems of different units. The results are relevant for applications of magnesium orotates in magnesium therapy.