Genetic variation of orosomucoid (ORM) in the genus Macaca was investigated. Plasma samples were subjected to isoelectric focusing in a pH range of 4-6.5, followed by immunoprinting with anti-human ORM antibodies. A total of 25 alleles were identified in 23 1 Asian macaques belonging to 13 species from 23 populations and 22 members belonging to a family of M. fusciculuris. Family data presented evidence for a codominant mode of inheritance with multi-alleles at a single auto-soma1 locus. A population study revealed enormous intra-and interspecies variations. The heterozygosity values varied from 0.855 in M. fusciculuris (Malaysia) to 0.000 in M . rudiutu (India), M. silenus (India) and M . urctoides (Malaysia). ' 6 *? *R * 9 *10 *11 *12 *13 *14 *15 *16 *17 *18 *19 *20 *21 *22 " 2 3 *24 Total Fascicularis group M. f, fuscuta (Shimokita, Japan) M. f. fuscufu (Fukushima, lapan) M. f. fuscafa (Ryozenyama, Japan) M. f fumzta (Wakasa, Japan) M. f. fuscuta (Takasakiyama, Japan) M. f. ~U S C Q ~~ (Koshima, Japan) M. I. yakui (Yaku is., Japan) M. cycIopis (Taiwan) M. rnuhrtu (India) 1M. mulatt~ (China) M. fascimhris (Indonesia) M. fascicuiaris (Malaysia) M. fasciculmis (Philippines) M. sinicu (Sri Lanka) M. radiata (India) IW. assamemis (India) M. arctoides (Thailand) M. mctoides (Malaysia) Sinica group Arctoides group Silenus group M. silenus (India) M. nemesrrina (Thailand) M. maurns (Sulaaesi, Indonesia) 10