✦ LIBER ✦

Orobuccal dyskinesia associated with trihexyphenidyl therapy in a patient with parkinson's disease

✍ Scribed by Robert A. Hauser; Dr. C. W. Olanow

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 284 KB
Volume: 8
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870080417

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Dyskinesia is a common adverse effect complicating chronic dopaminergic therapy for Parkinson's disease. Movements are frequently choreic in nature and have been ascribed to overstimulation of “supersensitive” striatal postsynaptic dopamine receptors. Anticholinergic medications, despite some clinical efficacy in Parkinson's disease, have rarely been reported to cause dyskinesia. We report a patient with Parkinson's disease who developed orobuccal dyskinesia while being treated with trihexyphenidyl (Artane). Dyskinesia was observed following the introduction of trihexyphenidyl, resolved with its discontinuation, and reappeared with its reinstitution. Carbidopa‐levodopa (Sinemet) alone did not cause dyskinesia but augmented dyskinesia associated with trihexyphenidyl.

📜 SIMILAR VOLUMES

Ocular dyskinesias in patients with Park

Ocular dyskinesias in patients with Parkinson's disease treated with levodopa

✍ Natsue Shimizu; Dr. Bernard Cohen; Stanley P. Bala; Marina Mendoza; Melvin D. Ya 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 459 KB 👁 2 views

Tics in a patient with Parkinson's disea

Tics in a patient with Parkinson's disease

✍ Dr. Heidi Shale; Stanley Fahn; Richard Mayeux 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 356 KB 👁 1 views

A patient with Gilles de la Tourette syndrome later developed Parkinson's disease in middie age. This was accompanied by amarkedreduction in the frequency of tics but levodopa toxicity exacerbated the tics. The dopamine hypothesis of tic disorders is supported by this observation.

Weight-loss associated with anti-dementi

Weight-loss associated with anti-dementia drugs in a patient with Parkinson's disease

✍ Adeline Gallini; Agnès Sommet; Anne-Marie Salandini; Patrick Veyssière; Jean-Lou 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 45 KB

Fatal gastroparesis in a patient with Pa

Fatal gastroparesis in a patient with Parkinson's disease

✍ Neal Hermanowicz 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB 👁 1 views

rCBF changes associated with PPN stimula

rCBF changes associated with PPN stimulation in a patient with Parkinson's disease: A PET study

✍ Antonio P. Strafella; Andres M. Lozano; Benedicte Ballanger; Yu-Yan Poon; Anthon 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

## Abstract Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modula

Use of complementary therapies in patien

Use of complementary therapies in patients with Parkinson's disease in Singapore

✍ Louis C.S. Tan; Puay-Ngoh Lau; Roland Dominic G. Jamora; Edwin S.Y. Chan 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 1 views

## Abstract To determine the frequency and spectrum of complementary therapy (CT) use and its association with sociodemographic or disease‐specific characteristics among Asian patients with Parkinson's disease (PD) in Singapore, we interviewed 159 patients using a structured questionnaire. Sixty‐on