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Ornithine decarboxylase and polyamines in developing rat brain and heart: Effects of perinatal hypothyroidism

โœ Scribed by Slotkin, Theodore A.; Johnson, Anne; Whitmore, William L.; Slepetis, Ruta J.

Book ID
122700900
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
476 KB
Volume
2
Category
Article
ISSN
0736-5748

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Effects of gestational or neonatal treat
Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry
โœ M. Sparapani; M. Virgili; M. Caprini; F. Facchinetti; E. Ciani; A. Contestabile ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 895 KB

Pregnant rats were treated for five consecutive days during gestation with s.c. injections of the ornithine decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO). Treatment beginning at gestational days 13 or 14 was effective in inhibiting ODC and altering polyamine levels, and resulted