## ABSTRACT Nonβsteroidal antiβinflammatory drugs (NSAIDs) are drugs used primarily to treat inflammation, pain and fever. Their main mechanism of action is cyclooxygenase (COX) inhibition, and this enzyme has been linked to hepatotoxicity. The association of COX and liver injury has been, in part,
Ornithine decarboxylase activity in acute and chronic CCl4 - induced liver damage
β Scribed by S. Antoniello; M. Auletta; F. Pardo
- Book ID
- 118568668
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 79 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0168-8278
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The importance of hydroxyl groups in the antioxidant and hepatoprotective properties of resveratrol was investigated. To achieve this, resveratrol or its trimethylated analog were administered (10 mg kg - ----1 , p.o.) to male Wistar rats and liver damage was induced by acute administration of CCl 4
The effects of ethanol on liver regeneration are poorly understood. Acute and chronic exposure to ethanol have been found to exert opposite effects on the induction of ornithine decarboxylase, the rate-limiting enzyme for polyamine biosynthesis. Polyamines are necessary for DNA synthesis and liver r