Origins of systemic lupus erythematosus: genes, environment, and host immune response
β Scribed by JB Harley, JA Kelly, JA James
- Book ID
- 120708088
- Publisher
- BioMed Central
- Year
- 2003
- Tongue
- English
- Weight
- 554 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1478-6354
- DOI
- 10.1186/ar827
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Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030.Β The urgency of the issue was demonst
## Abstract In normal individuals T cells are stimulated to proliferate by autologous nonβT cells; this is called the autologous mixed lymphocyte reaction (MLR). Previous studies demonstrated that such an autologous MLR was markedly impaired in patients with active systemic lupus erythematosus (SLE