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Origins and selection of p53 mutations in lung carcinogenesis

✍ Scribed by Sergei N Rodin; Andrei S Rodin

Book ID
113900182
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
341 KB
Volume
15
Category
Article
ISSN
1044-579X

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## Abstract In a total of 26 primary human lung tumors and 60 metastases derived from them, exons 5–8 of the __p53__ tumor suppressor gene were analyzed by single‐strand conformation polymorphism and subsequent direct DNA sequencing of amplified DNA. Mutational inactivation of the __p53__ gene was