✦ LIBER ✦

Origins and consequences of centrosome aberrations in human cancers

✍ Scribed by Erich A. Nigg

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 298 KB
Volume: 119
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.22245

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recent years have seen a revival of interest in the possible contribution of centrosomes to the development of human cancers. The underlying hypothesis, formulated almost 100 years ago (Boveri T. The origin of malignant tumors; Baltimore, MD: Williams and Wilkins, 1929.), states that numerical and/or structural centrosome abnormalities will cause me missegregation. In addition, centrosome abnormalities are expected to affect cell shape, polarity, and motility. Thus, deregulation of centrosome number and function may foster both chromosomal instability and loss of tissue architecture—2 of the most common phenotypes associated with solid human tumors. In support of the role of centrosome deregulation in tumorigenesis, centrosome aberrations have been observed in early, premalignant lesions. Moreover, they are frequent in many different types of common tumors and their prominence often correlates with poor clinical outcome. This review addresses the origins of centrosome aberrations in human tumors as well as the expected impact of centrosome aberrations on cell fate and tumor development. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Association between TP53 gene ARG72PRO p

Association between TP53 gene ARG72PRO polymorphism and chromosome aberrations in human cancers

✍ Nicolay V. Litviakov; Evgeny V. Denisov; Ravil' M. Takhauov; Andrey B. Karpov; E 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 1 views

## Abstract It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the well‐known Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actuall

Centrosomal aberrations in primary invas

Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression

✍ Andreas Schneeweiss; Hans-Peter Sinn; Volker Ehemann; Tanja Khbeis; Kai Neben; U 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 117 KB

## Abstract Our purpose was to assess the presence of centrosomal aberrations as measured by immunohistochemistry in primary invasive breast cancer and their association with established and proposed prognostic factors. Tissue sections of 103 primary invasive breast cancers were examined using cent

The presence of high-risk chromosome abe

The presence of high-risk chromosome aberrations in chronic lymphocytic leukaemia does not correlate with centrosome aberrations

✍ Laura Ottaggio; Annalisa Zunino; Irena Maric; Alessia Grozio; Edoardo Rossi; Mau 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB 👁 1 views

## Abstract Chromosome aberrations are frequently found in B‐cell chronic lymphocytic leukaemia (B‐CLL), and specific chromosome aberrations identify poor prognostic subgroups. Almost all the aberrations identified in B‐CLL involve loci where genes with a role in the regulation of centrosome duplic

Functional consequences of mutations in

Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers

✍ Tsuneo Ikenoue; Fumihiko Kanai; Yohko Hikiba; Yasuo Tanaka; Jun Imamura; Miki Oh 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB

## Abstract Mutations in the __B‐raf__ gene have been reported in a number of human cancers, including melanoma and lung cancer. More than 80% of the reported B‐raf mutations were V599E; however, non‐V599E mutations have been frequently found in non‐small cell lung cancers as compared with melanoma

Centrosome amplification and instability

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

✍ B. Michael Ghadimi; Dan L. Sackett; Michael J. Difilippantonio; Evelin Schröck; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 578 KB

Measurement of the nuclear DNA content allows classification of human cancers as either diploid or aneuploid. To gain further insight into mechanisms of aneuploidy, we compared the cytogenetic profile of mismatch-repair-deficient diploid versus mismatch-repair-proficient aneuploid colorectal carcino

Aberrant methylation of EphA7 in human p

Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features

✍ Ming Guan; Chong Xu; Fanglin Zhang; Chuanzhong Ye 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 436 KB 👁 2 views

## Abstract __EphA7__ is a member of __Eph/ephrins__ family and play diverse roles in carcinogenesis. The aim of our study was to investigate functional and structural alterations of EphA7 in prostate cancer and determine if those findings correlate with the clinicopathologic features of prostate c