Origin of YAP+ lineages of the human Y-chromosome

✍ Scribed by Bravi, Claudio M.; Bailliet, Graciela; Martínez-Marignac, Verónica L.; Bianchi, Néstor O.

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 116 KB
• Volume: 112
• Category: Article
• ISSN: 0002-9483
• DOI: 10.1002/(sici)1096-8644(2000)112:2<149::aid-ajpa2>3.0.co;2-m

✦ Synopsis

We screened a total of 841 Y-chromosomes representing 36 human populations of wide geographical distribution for the presence of a Y-specific Alu insert (YAPϩ chromosomes). The Alu element was found in 77 cases. We tested 5 biallelic and 8 polyallelic markers in 70 out of the 77 YAPϩ chromosomes. We could identify the existence of a hierarchical and chronological structuring of ancestral and derived YAPϩ lineages, giving rise to 4 haplogroups, 14 subhaplogroups and 60 haplotypes. Moreover, we propose a monophyletic origin for each one of the YAPϩ lineages. Out-of-Africa and out-of-Asia models have been suggested to explain the origin and evolution of ancestral and derived YAPϩ elements. We analyze the evidence supporting these two hypotheses, and we conclude that the information available does not allow one to decide between the out-of-Asia or out-of-Africa models.