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Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

✍ Scribed by Philip A. S. Lowden; Barrie Wilkinson; Günter A. Böhm; Sandeep Handa; Heinz G. Floss; Peter F. Leadlay; James Staunton

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
75 KB
Volume
40
Category
Article
ISSN
0044-8249

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The biosynthesis of daunorubicin and its precursors proceeds via the condensation of nine C-2 units derived from malonyl-CoA onto a propionyl starter moiety. The daunorubicin polyketide biosynthesis gene cluster of Streptomyces sp. strain C5 has two unique open reading frames, dpsC and dpsD, encodin