Origin and divergence of tandem repeats of primate D4 dopamine receptor genes
β Scribed by Miho Inoue-Murayama; Osamu Takenaka; Yuichi Murayama
- Book ID
- 110555371
- Publisher
- Springer Japan
- Year
- 1998
- Tongue
- English
- Weight
- 505 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0032-8332
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The dopamine D4 receptor (DRD4) is a member of the D2-like dopamine receptor family. Polymorphisms at the DRD4 gene have been examined for association with a wide range of neuropsychiatric disorders and normal behavioral variation. The DRD4 gene is unusual in its high amount of expressed polymorphis
The dopamine D4 receptor (DRD4) gene exhibits a large amount of expressed polymorphism in humans. To understand the evolutionary history of the first exon of DRD4which in humans contains a polymorphic 12bp tandem duplication, a polymorphic 13bp deletion, and other rare variants-we examined the homol