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Oridonin-induced apoptosis of Jurkat cells and its mechanism

✍ Scribed by Jiajun Liu; Renwei Huang; Dongjun Lin; Xiangyuan Wu; Xinyao wu; Huiling Lu; Xianglin Pan; Jun Peng; Mingquan Li; Qu Lin


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
271 KB
Volume
13
Category
Article
ISSN
1618-5641

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## Abstract T‐cell depletion is found in enterovirus 71 (EV71)‐infected patients with pulmonary edema. However, the mechanism that causes T‐cell depletion is unclear. To address this question, the effects of EV71 infection on the cell viability of human Jurkat T cells were studied. Viable viruses w

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Oridonin, an ent-kaurane diterpenoid derived from the herbal Rabdosia rubescens, has been recently reported to have antitumor effects on a large variety of cancer cells. The present study was undertaken to investigate the in vitro antiproliferation and apoptosis inducing effects of oridonin on HPB-A

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## Abstract Jurkat T‐lymphocytes lack p53 and Bax but contain p73 and Bid and are killed by etoposide (ETO). With ETO c‐abl is phosphorylated and phosphorylated p73 increased. Translocation of full‐length Bid to mitochondria follows, with induction of the mitochondrial permeability transition (MPT)