Organometallic complexes with biological molecules. IX. Diorgano- and triorgano-tin(IV)[meso-tetra (4-sulfonatophenyl)porphinate] derivatives: solid-state and solution-phase structural aspects and in vivo effects

✍ Scribed by A. Pellerito; T. Fiore; A. M. Giuliani; F. Maggio; L. Pellerito; C. Mansueto

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 282 KB
• Volume: 11
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/(sici)1099-0739(199709)11:9<707::aid-aoc632>3.0.co;2-j

✦ Synopsis

Diorgano-and triorgano-tin(IV) derivatives of meso-tetra(4-sulfonatophenyl)porphine (H 4 TPPS) with general formula (R 2 Sn) 2 TPPS and (R 3 Sn) 4 TPPS (TPPS 4 Ϫ = [meso-tetra(4-sulfonatophenyl)porphinate] 4 Ϫ , R = Me, Bu, Ph) have been obtained and their solid-state configuration inferred on the basis of IR and Mössbauer spectroscopy, while solution-phase studies have been carried out by 1 H and 13 C NMR in DMSO-d 6 , together with determination of the in vivo cytotoxicity of the new derivatives towards embryonic development of Ciona intestinalis. In particular, octahedral and trigonal-bipyramidal eq-R 3 Sn polymeric configurations are proposed, in the solid state, respectively for (R 2 Sn) 2 TPPS and (R 3 Sn) 4 TPPS complexes, with the arylsulfonate groups behaving as monoanionic bidentate bridging ligands.

The 1 H and 13 C NMR data lead to the conclusion that the metal-to-ligand ratio (2 :1 or 4 :1), binding site (the sulfonato-group oxygens), and the coordination polyhedron around the metal (trans-octahedral or trigonal-bipyramidal) found in the solid state are preserved in solution.