Organolithiums in Enantioselective Synthesis

✍ Scribed by David M. Hodgson, Matthew A. H. Stent (auth.), Dr. David M. Hodgson (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2003
• Tongue: English
• Leaves: 324
• Series: Topics in Organometallic Chemistry 5
• Edition: 1
• Category: Library

✦ Synopsis

Organolithium chemistry occupies a central position in the selective construction of C-C bonds in both simple and complex molecules. Paralleling the surge of interest in methods for asymmetric synthesis, the use of organolithiums in enantioselective synthesis has witnessed spectacular advances in a little over a decade. This volume is the first dedicated to a comprehensive coverage of this important area. It is designed to provide graduate students and researchers with a rich source of essential information on synthesising molecules in an enantioselective manner using organolithiums, and be an inspiration for future developments. Following an overview chapter summarising the key milestones, successive chapters, each written by leading experts in their field, critically survey all the major areas of progress.

✦ Table of Contents

Overview of Organolithium-Ligand Combinations and Lithium Amides for Enantioselective Processes....Pages 1-20
Enantioselective Addition of Organolithiums to C=O Groups and Ethers....Pages 21-36
Enantioselective Conjugate Addition and 1,2-Addition to C=N of Organolithium Reagents....Pages 37-59
Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Electrophile Incorporation....Pages 61-138
Enantioselective Synthesis by Lithiation Adjacent to Nitrogen and Electrophile Incorporation....Pages 139-176
Enantioselective Synthesis by Lithiation Adjacent to Sulfur, Selenium or Phosphorus, or without an Adjacent Activating Heteroatom....Pages 177-216
Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Subsequent Rearrangement....Pages 217-250
Enantioselective Synthesis by Lithiation to Generate Planar or Axial Chirality....Pages 251-286
Enantioselective Carbolithiations....Pages 287-310

✦ Subjects

Organometallic Chemistry; Inorganic Chemistry; Medicinal Chemistry