Organochromium complexes - labelled aminoglycoside antibiotics derived from kanamycin A and tobramycin. Synthesis, structural characterization and use as metallotracers for immunoassays.
✍ Scribed by Jan Szymoniak; Bouchra El Mouatassim; Jack Besançon; Claude Moïse; Pierre Brossier
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 570 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The synthesu of mctallocenrc denvatrves of amtnoglycostde antrbtotrcs. I e hnamyan A and tobramycm, 16 desertbed The oqanometatl&abelled compounds have been obtatnedfrom the reactwn between thepolyamtnodrugs and or&znochro~um esters of N-hydroxysuccuwntde The reaction proceeded seiecuvely at the 6'-Nposrtton. as m&t be dehced both from the rrmss and the pH-dependent 13C-NMR spectra The procedure could be regarded as generally urcfulfor the metal~olabellmg ~aRUUO&OSl& antrbtottcs As an example of appltcatton a compettttve nmnwwas say based on the use of these labels IS proposed