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Organocatalyzed Cyclopropanation of α-Substituted α,β-Unsaturated Aldehydes: Enantioselective Synthesis of Cyclopropanes Bearing a Chiral Quaternary Center

✍ Scribed by Vincent Terrasson; Arie van der Lee; Renata Marcia de Figueiredo; Jean Marc Campagne


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
283 KB
Volume
16
Category
Article
ISSN
0947-6539

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Diastereoselective Cyclopropanation of α,β-Unsaturated Acetals of a Novel Camphor-Derived Chiral Auxiliary. -2-exo-3-exo-Dihydroxybornane-10-sulfonate (III) proves to be a highly efficient chiral auxiliary for the asymmetric Simmons-Smith cyclopropanation of α,βunsaturated acetal derivatives [cf.