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Organocatalytic Asymmetric Michael Addition of Oxindoles to Nitroolefins for the Synthesis of 2,2-Disubstituted Oxindoles Bearing Adjacent Quaternary and Tertiary Stereocenters

โœ Scribed by Jin, Cheng-Yong; Wang, Yao; Liu, Yao-Zong; Shen, Chao; Xu, Peng-Fei


Book ID
118164542
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
317 KB
Volume
77
Category
Article
ISSN
0022-3263

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Organocatalytic Asymmetric Michael Addit
โœ Yu-Hua Liao; Wen-Bing Chen; Zhi-Jun Wu; Xi-Lin Du; Lin-Feng Cun; Xiao-Mei Zhang; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 209 KB ๐Ÿ‘ 1 views

## Abstract The first organocatalytic diastereoโ€ and enantioselective Michael addition reaction of 4โ€substitutedโ€pyrazolinโ€5โ€ones to nitroolefins has been developed with a chiral bifunctional thiourea as organocatalyst. A wide variety of desired multiโ€substituted pyrazolinโ€5โ€one derivatives with co