Organocatalytic Asymmetric Aza-Michael Additions

✍ Scribed by Dieter Enders; Chuan Wang; Jens X. Liebich

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 934 KB
• Volume: 15
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.200902236

✦ Synopsis

Abstract

The catalytic aza‐Michael addition is an important reaction within synthetic organic chemistry, given the significance of the biologically and synthetically interesting products, such as β‐amino acids and β‐lactams. In the last decade organocatalysis emerged as a powerful tool in asymmetric synthesis and had a large impact on the development of asymmetric and catalytic conjugate additions of nitrogen nucleophiles to Michael acceptors. In this review a first summary of the recent rapid progress of asymmetric organocatalyzed aza‐Michael reactions is presented.