✦ LIBER ✦
Organoaluminium induced ring-opening of epoxypyranosides. IV. Synthesis and structure of γ- hydroxy-lsoleucine stereoisomers and their corresponding lactones.
✍ Scribed by Tord Inghardt; Torbjörn Frejd; Göran Svensson
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 919 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0040-4020
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✦ Synopsis
Key Wordy: tnmethylaluminium; opening of epoxide and pymnoside rings; 2.3~anhydr+L-ribopyranosik y-hydroxy-i&wine;
x-ray data.
Abstmct: Two r hydroxy-isoleucine stereoisomers 8 (2R. 3R, 4R), and 14 (2s. 3R, 4R) as well as their corresponding y lactones 9 and IS were synthesised using a tandem, Me3Al induced open& of the epoxide and pyranoside rings of benzyl23-anhydro4-O-(terr-buyldmze~hylsilyl)-~L-ribopyranos& (I). The structure of the iactone hydrochloride 9
was confirmed by an X-ray crystal structure determutation.