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Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase

✍ Scribed by Jesús F. Aparicio; István Molnár; Torsten Schwecke; Ariane König; Stephen F. Haydock; Lake Ee Khaw; James Staunton; Peter F. Leadlay

Book ID: 116133342
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 914 KB
Volume: 169
Category: Article
ISSN: 0378-1119
DOI: 10.1016/0378-1119(95)00800-4

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## Abstract __The oviedomycin biosynthetic gene cluster from__ Streptomyces antibioticus __ATCC 11891 has been sequenced and characterized. It contains all the necessary genes for oviedomycin biosynthesis, together with several genes for the generation of malonyl‐CoA extender units. Production of t