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Organization of spliceosomal U6 snRNA genes in the mouse genome

✍ Scribed by Yan Yuan; Ram Reddy

Book ID: 104776846
Publisher: Springer
Year: 1989
Tongue: English
Weight: 426 KB
Volume: 13
Category: Article
ISSN: 0301-4851
DOI: 10.1007/bf00444312

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✦ Synopsis

U6 RNA is an abundant small nuclear RNA (snRNA) required for splicing of pre-mRNAs. In mammaiian cells, the genes for U 1 to U4 snRNAs consist of multigene families ranging from 10 to 100 copies of real genes per haploid genome, and are transcribed by RNA polymerase II. In contrast, results obtained in this study indicate that U6 RNA, which is transcribed by RNA polymerase II and III, may be coded for in mouse cells by only two genes. These two U6 genes are at least 9 kb apart from each other, and the flanking sequences are highly conserved, indicating that the organization of U6 genes is similar to that observed for other mammalian U-snRNA genes.

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