✦ LIBER ✦

Organization of ground substance proteoglycans in normal and osteoarthritic knee cartilage

✍ Scribed by Kenneth D. Brandt; Marshall Palmoski

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 595 KB
Volume: 19
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780190213

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A study of the organization of proteoglycans in articular cartilage indicates that nonaggregated proteoglycans existed in larger numbers in osteoarthritic than in normal cartilage and that proteoglycan aggregates in arthritic cartilage were smaller than normal. After dissociation from hyaluronic acid and tissue glycoproteins, no difference in hydrodynamic size of disaggregated proteoglycans was noted, but chondroitin sulfate chains of those from diseased cartilage were shorter than normal. The data suggest that there is a defect in proteoglycan aggregation in osteoarthritic cartilage which could be of pathogenetic significance.

📜 SIMILAR VOLUMES

Degradation of proteoglycans in human os

Degradation of proteoglycans in human osteoarthritic cartilage

✍ Dr. Roy D Altman; Julio C Pita; David S Howell 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 702 KB

Osteoarthritic synovial tissue inhibitio

Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage–synovium coculture

✍ Michiel Beekhuizen; Yvonne M. Bastiaansen-Jenniskens; Wendy Koevoet; Daniel B. F 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 628 KB

Neutral proteases capable of proteoglyca

Neutral proteases capable of proteoglycan digesting activity in osteoarthritic and normal human articular cartilage

✍ Dr Johanne Martel-Pelletier; Jean-Pierre Pelletier; Jean-Marie Cloutier; David S 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 767 KB

Proteases have been postulated to account for the progressive disappearance of matrix proteoglycans in osteoarthritic (OA) cartilage. The digestion of endogenous proteoglycans by neutral proteases in human OA cartilage homogenates has been measured and compared with that of normal age-matched contro

Comparative rates of proteoglycan synthe

Comparative rates of proteoglycan synthesis and size of proteoglycans in normal and osteoarthritic chondrocytes

✍ Ryota Teshima; Benjamin V. Treadwell; Carol A. Trahan; Henry J. Mankin 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 575 KB

Metabolism of a cartilage matrix glycopr

Metabolism of a cartilage matrix glycoprotein in normal and osteoarthritic canine articular cartilage

✍ Rose S. Fife; Marshall J. Palmoski; Kenneth D. Brandt 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 668 KB

We have recently described a 550,000-dalton nomollagenous cartilage matrix glycoprotein (CMGP), with subunits of 130,000, which is present in hyaline cartilage and fibrocartilage. Biosynthetic studies indicated that CMGP was synthesized by short-term organ cultures of normal canine articular cartila

Changes in messenger rna and protein lev

Changes in messenger rna and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples

✍ Gabriella Cs-Szabó; Lee I. Melching; Peter J. Roughley; Tibor T. Glant 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 938 KB