✦ LIBER ✦
Organic reactions at high pressure. A mild method for the placement of protecting groups on hindered and sensitive alcohols
✍ Scribed by William G Dauben; Richard A Bunce; John M Gerdes; Kevin E Henegar; Allan F Cunningham Jr.; Thomas B Ottoboni
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 268 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A series of hindered and/or labile alcohols has been derivatized with a variety of acylating and silylating agents using pyridine in methylene chloride at 15 kbar (1.5 GPa) pressure to afford excellent yields of protected alcohols at 20 "C, largely without the need for added DMAP.
Methoxyethoxymethyl chloride reacted in moderate yield using N,B-diisopropylethylamine under the high pressure conditions.