Organ specificity of metastatic tumor colonization is related to organ-selective growth properties of malignant cells

Patterning of B16 melanoma metastasis an

Patterning of B16 melanoma metastasis and colonization generally relates to tumor cell growth-stimulating or growth-inhibiting effects of organs and tissues

✍ E. F. Valle; A. D. Zalka; L. Groszek; C. W. Stackpole 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 924 KB

The mouse B16 melanoma metastasizes first to the lungs and secondarily to systemic sites, involving mainly the adrenals, ovaries and pancreas. Systemic colonization effected by intracardiac injection of tumor cells establishes similar patterning, but in addition frequently colonizes the bones. To as