Organ Size Control by Hippo and TOR Pathways
✍ Scribed by Karen Tumaneng; Ryan C. Russell; Kun-Liang Guan
- Book ID
- 113563936
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 555 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0960-9822
No coin nor oath required. For personal study only.
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## Abstract Organ size control is a fundamental and core process of development of all multicellular organisms. One important facet of organ size control is the regulation of cell proliferation and cell death. Here we address the question, What are the developmental mechanisms that control intrinsi
## Abstract The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase W