Organ blood flow and brown adipose tissue oxygen consumption during noradrenaline-induced nonshivering thermogenesis in the djungarian hamster

✍ Scribed by Puchalski, Wolfgang ;Böckler, Heinz ;Heldmaier, Gerhard ;Langefeld, Martin

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 626 KB
• Volume: 242
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1402420304

✦ Synopsis

During NA-induced NST blood flow through BAT increased from 0.18 ml min to 3.21 ml min-' in 23 "C acclimated (equals thermoneutrality) and from 0.61 ml min-' to 9.67 ml min in outdoors (-2 to 12°C T,) acclimated Djungarian hamsters. In 23 "C acclimated hamsters this increase was accomplished by a diversion of blood flow from visceral organs without a change in cardiac output (19.7 versus 20.5 ml min-' before and after NA). In outdoors acclimated hamsters we also observed a redistribution of blood flow from the viscera to BAT. In addition, cardiac output increased from 24.3 to 38.8 ml min-l. Metabolic rate of BAT in situ was determined from organ blood flow and the (A-V)02 of blood across the interscapular BAT. BAT of outdoor acclimated hamsters showed a significantly higher metabolism in comparison to 23 "C acclimated hamsters (81.1 versus 30.4 m102h-1). Furthermore, this calculation revealed that 28% (23 "C acclimated hamsters) and 61% (outdoors acclimated hamsters) of total NST were located in BAT of Phodopus sungorus.