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Orally Bioavailable Benzisothiazolone Inhibitors of Human Leukocyte Elastase

โœ Scribed by Hlasta, Dennis J.; Subramanyam, Chakrapani; Bell, Malcolm R.; Carabateas, Philip M.; Court, John J.; Desai, Ranjit C.; Drozd, Marion L.; Eickhoff, W. Mark; Ferguson, Edward W.; Gordon, Robert J.; Dunlap, Richard P.; Franke, Catherine A.; Mura, Albert J.; Rowlands, Anne; Johnson, Judith A.; Kumar, Virendra; Maycock, Alan L.; Mueller, Karl R.; Pagani, Edward D.; Robinson, David T.; Saindane, Manohar T.; Silver, Paul J.; Subramanian, Sandhya


Book ID
127002541
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
752 KB
Volume
38
Category
Article
ISSN
0022-2623

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[14C]-labelling of benzisothiazolone bas
โœ Alain Burgos; Gordon R. Duffin; George J. Ellames; Karen J. Wedge ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 418 KB

The [ 4C] labelled synthesis of two benzisothiazolone based inhibitors of Human Leukocyte Elastase is described. These are The synthesis of the intermediate [3-14C]-2-(chloromethyl)-6-methoxy-4-( l-methylethyl)-l,2benzisothiazol-3(2H)-one 1 ,I-dioxide, 8, common to both these syntheses. was achieve