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Oral pulsatile delivery: Rationale and chronopharmaceutical formulations

✍ Scribed by Alessandra Maroni; Lucia Zema; Maria Dorly Del Curto; Giulia Loreti; Andrea Gazzaniga

Book ID
108147141
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
320 KB
Volume
398
Category
Article
ISSN
0378-5173

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Selegiline is a selective, irreversible inhibitor of MAO-B, used in the treatment of Parkinson's disease, either alone or as an adjunct to L-DOPA. The sole recommended dosing regimen is 5 mg given in the morning and at noon with breakfast and lunch. A pulsatile oral dosage form was developed to mimi