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Oral melphalan pharmacokinetics — relation to dose in patients with multiple myeloma

✍ Scribed by Hans Ehrsson; Staffan Eksborg; Anders Österborg; Håkan Mellstedt; Astrid Lindfors

Book ID
112962910
Publisher
Springer US
Year
1989
Tongue
English
Weight
273 KB
Volume
6
Category
Article
ISSN
1357-0560

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✍ C. G. Adair; J. M. Bridges; Z. R. Desai 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 329 KB

Pharmacokinetic studies in 11 patients with multiple myeloma were undertaken on the first and last days of one course of chemotherapy. The drug was administered PO in single doses of 6-14 mg daily. Melphalan concentrations were determined by high-performance liquid chromatography. The interpatient v