Oral biovailability of heparin using a novel delivery system
β Scribed by James M. Dunn; Alan S. Hollister
- Book ID
- 115851637
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 586 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0011-393X
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Low molecular weight heparin (LMWH) is an agent of choice in the anticoagulant therapy and prophylaxis of thrombosis and coronary syndromes. However, the therapeutic use is partially limited due to a poor oral bioavailability. It was therefore the aim of this study to design and evaluate a highly ef
Previously we proposed a heparin/protamine-based system for delivery of protease drugs such as tissue-specific plasminogen activator (tPA). To demonstrate the feasibility of this approach as well as its pro-drug and triggered release features, positively charged peptides [(Arg) 7 Cys] were successfu