Oral bioavailability and intestinal absorption of candesartan cilexetil: role of naringin as P-glycoprotein inhibitor

Multiple pathways are involved in the or

Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: Role of paracellular transport, binding to trypsin, and P-glycoprotein efflux

✍ Amrita V. Kamath; Richard A. Morrison; Timothy W. Harper; Shih-Jung Lan; Anthony 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

BMS-262084 is a potent and selective b-lactam tryptase inhibitor with therapeutic potential for treating asthma. The oral bioavailability of BMS-262084 was low in rats (4% at a dose of 0.5 mg/kg) due to poor absorption. BMS-262084 was excreted mainly unchanged in the urine, suggesting minimal metabo