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Oral activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice

โœ Scribed by Liangli Zhao; Philip Kestell; Lai-Ming Ching; Bruce C. Baguley


Publisher
Springer
Year
2002
Tongue
English
Weight
171 KB
Volume
49
Category
Article
ISSN
0344-5704

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A new short synthesis of 5,6-dimethylxan
โœ Shangjin Yang; William A. Denny ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 217 KB

A new short synthesis of 5,6-dimethylxanthenone-4-acetic acid (ASA404) is developed. The key steps of the synthesis are dibromination of 3,4-dimethylbenzoic acid, followed by regioselective coupling with 2hydroxyphenylacetic acid and subsequent cyclodehydration.