Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle
✍ Scribed by Zoe Allen Martinez; Mark Colgan; Lewis R. Baxter Jr.; Javier Quintana; Stefan Siegel; Arion Chatziioannou; Simon R. Cherry; John C. Mazziotta; Michael E. Phelps
- Book ID
- 101266293
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 121 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0275-2565
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✦ Synopsis
We describe a method of orally administering 18 F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMR-Glcs for brain structures, relative to each other, in non-restrained, nondrugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children. Am.