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OR02-5 Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of the insulin receptor isoform A

✍ Scribed by Morrione, A.; Morcavallo, A.; Genua, M.; Palummo, A.; Kletvikova, E.; Jiracek, J.; Brzozowski, A.M.; Iozzo, R.V.; Belfiore, A.


Book ID
123108131
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
55 KB
Volume
22
Category
Article
ISSN
1096-6374

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## Abstract Insulin‐like growth factor II (IGF‐II) plays a key role in mitogenesis during development and tumorigenesis and is believed to exert its mitogenic functions mainly through the IGF‐I receptor. Recently, we identified the insulin receptor isoform A (IR^A^) as an additional high affinity r