Optional Exon in the 5′-untranslated Region of 3-hydroxy-3-methylglutaryl Coenzyme A Synthase Gene: Conserved Sequence and Splicing Pattern in Humans and Hamsters

A frequent TG deletion near the polyaden

A frequent TG deletion near the polyadenylation signal of the human HEXB gene: Occurrence of an irregular DNA structure and conserved nucleotide sequence motif in the 3′ untranslated region

✍ FE Kleiman; A. Oller Ramírez; B Akerman; R Dodelson de Kremer; RA Gravel; CE Arg 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

While screening for new mutations in the HEXB gene, which encodes the beta-subunit of beta-hexosaminidase, a TG deletion (deltaTG) was found in the 3' untranslated region (3'UTR) of the gene, 7 bp upstream from the polyadenylation signal. Examination of DNA samples of 145 unrelated Argentinean indiv