Treatment of Philadelphia-chromosome-pos
✍
Yoshio Honma; Yoshinobu Matsuo; Yasuhide Hayashi; Satoshi Omura
📂
Article
📅
1995
🏛
John Wiley and Sons
🌐
French
⚖ 731 KB
The molecular basis of the Philadelphia chromosome (Ph') is a structurally altered c-abl (bcr-abl) gene which encodes an abnormally large protein with protein tyrosine kinase activity. Herbimycin A, which effectively reduced intracellular phosphorylation by bcr-abl tyrosine kinase, preferentially in