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Optimizing Treatment with Bcr-Abl Tyrosine Kinase Inhibitors in Philadelphia Chromosome—Positive Chronic Myeloid Leukemia: Focus on Dosing Schedules

✍ Scribed by Jabbour, Elias; Cortés, Jorge E.; Kantarjian, Hagop


Book ID
119936057
Publisher
CIG Media Group, LP.
Year
2008
Tongue
English
Weight
138 KB
Volume
8
Category
Article
ISSN
1557-9190

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The molecular basis of the Philadelphia chromosome (Ph') is a structurally altered c-abl (bcr-abl) gene which encodes an abnormally large protein with protein tyrosine kinase activity. Herbimycin A, which effectively reduced intracellular phosphorylation by bcr-abl tyrosine kinase, preferentially in