✦ LIBER ✦

Optimizing the osteogenic potential of adult stem cells for skeletal regeneration

✍ Scribed by Jung Yul Lim; Alayna E. Loiselle; Jeong Soon Lee; Yue Zhang; Joshua D. Salvi; Henry J. Donahue

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 495 KB
Volume: 29
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.21441

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Adult stem cells, including mesenchymal stem cells, display plasticity in that they can differentiate toward various lineages including bone cells, cartilage cells, fat cells, and other types of connective tissue cells. However, it is not clear what factors direct adult stem cell lineage commitment and terminal differentiation. Emerging evidence suggests that extracellular physical cues have the potential to control stem cell lineage specification. In this perspective article, we review recent findings on biomaterial surface and mechanical signal regulation of stem cell differentiation. Specifically, we focus on stem cell response to substrate nanoscale topography and fluid flow induced shear stress and how these physical factors may regulate stem cell osteoblastic differentiation in vitro. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1627–1633, 2011

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