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Optimizing scale-up fermentation processes

✍ Scribed by Michel Thiry; Doriano Cingolani

Book ID
114152461
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
30 KB
Volume
20
Category
Article
ISSN
0167-7799

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Effect of various nutritional components and fermentation parameters on biotransformation of colchicine using Bacillus megaterium ACBT03 to produce 3-demethylated colchicine (3-DMC) has been investigated. Initially, Plackett-Burman (PB) design was used to evaluate the 11 nutritional variables to scr