Optimizing process time for utrafiltration and diafiltration

✍ Scribed by B.Ali Asbi; Munir Cheryan

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 669 KB
• Volume: 86
• Category: Article
• ISSN: 0011-9164
• DOI: 10.1016/0011-9164(92)80023-3

✦ Synopsis

Models have been derived to predict process time and permeate volume for the purification of a macromolecule by ultrafiltration (in the concentration mode) or by continuous diafiltration. It requires only knowledge of the parameters of the film theory (gel-polarization) model for flux. Purification by discontinuous diafiltration usually results in less time and generates lower permeate volume than continuous diafiltration alone. The optimum appears to be a combined process where the feed is first pre-concentrated by ultrafiltration, followed by continuous diafiltration.