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Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

✍ Scribed by Rand, Arthur C.; Leung, Siegfried S. F.; Eng, Heather; Rotter, Charles J.; Sharma, Raman; Kalgutkar, Amit S.; Zhang, Yizhong; Varma, Manthena V.; Farley, Kathleen A.; Khunte, Bhagyashree; Limberakis, Chris; Price, David A.; Liras, Spiros; Mathiowetz, Alan M.; Jacobson, Matthew P.; Lokey, R. Scott

Book ID
118039602
Publisher
The Royal Society of Chemistry
Year
2012
Tongue
English
Weight
338 KB
Volume
3
Category
Article
ISSN
2040-2503

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## Abstract Three 2,5‐substituted polar PPV derivatives have been prepared using the sulfinyl precursor route and compared to the apolar MDMO‐PPV. All polymers were obtained in excellent yield and with improved purity as compared to other methods. The influence of the polarity of the side chains, i