## Abstract Homocysteine (Hcy) is a risk factor for vascular diseases, cognitive impairment, and dementia. Elevated plasma concentrations of Hcy have been found recently in Parkinson's disease (PD) patients treated with levodopa, suggesting that levodopa is a cause of hyperhomocysteinemia (HHcy). T
Optimizing levodopa pharmacokinetics in Parkinson’s disease: the role of COMT inhibitor
✍ Scribed by F. Stocchi; L. Vacca; P. Grassini; G. Battaglia; M. Onofrj; M. Valente; S. Ruggieri
- Publisher
- Springer Milan
- Year
- 2003
- Tongue
- English
- Weight
- 52 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1590-1874
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Five patients with severe Parkinson's disease were characterized with respect to their pharmacokinetic and pharmacodynamic responses to levodopa given: orally, intravenously (three different infusion rates) and intraduodenally. The best therapeutic infusion rate in the intravenous study was used for