✦ LIBER ✦
Optimized synthesis of four isotopically labeled (13C-enriched) phenolic acids via a malonic acid condensation
✍ Scribed by Rebecca J. Robbins; Walter F. Schmidt
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- French
- Weight
- 124 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.869
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✦ Synopsis
Abstract
Four isotopically (^13^C)‐labeled phenolic acids (caffeic [M + 3], sinapic [M + 2], p‐coumaric [M + 6] and ferulic [M + 6] acids) were synthesized via a simple one‐step malonic acid condensation with a series of aldehydes. The aldehydes and the malonic acid were variously labeled and unlabeled to vary the enriched sites. ^13^C and ^1^H NMR analyses together confirmed the labeled positions. LC/MS confirmed the masses. These acids are intended for use as internal standards for isotope dilution mass spectrometry (IDMS). Copyright © 2004 John Wiley & Sons, Ltd.
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