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Optimization of yield in kinetically controlled synthesis of ampicillin with immobilized penicillin acylase in organic media

✍ Scribed by Andrés Illanes; Soledad Anjarí; Rosa Arrieta; Carolina Aguirre

Book ID
111635312
Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
414 KB
Volume
97
Category
Article
ISSN
0273-2289

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✍ Luuk M. van Langen; Natasja H. P. Oosthoek; Fred van Rantwijk; Roger A. Sheldon 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 82 KB

## Abstract Penicillin acylase (EC 3.5.1.11) from __Alcaligenes faecalis__, immobilised as a cross‐linked enzyme aggregate (CLEA), catalysed the synthesis of ampicillin in water‐miscible organic solvents at low water concentrations. Below 4% water (v/v) no reaction was observed, showing the crucial