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Optimization of Ultrasound-Mediated In Vitro Reversal of Multidrug Resistance in Human Hepatocarcinoma Cell Line HepG2

โœ Scribed by Bao-Jin Zhai; Ze-Yong Shao; Chun-Liang Zhao; Kai Hu; Ding-Ming Shen; Feng Wu


Book ID
108295642
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
263 KB
Volume
34
Category
Article
ISSN
0301-5629

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โœ Shunji Aoki; Andi Setiawan; Yasuhiro Yoshioka; Kouichi Higuchi; Ritsuko Fudetani ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 531 KB

We have isolated agosterol A (1) from a marine sponge of Spongia sp. as a reversing substance to multidrug resistance (MDR) in human carcinoma cell lines, KB-C2 and KB-CV60, overexpressing P-glycoprotein and MRP, respectively. Further investigation led us to isolate analogous sterols, agosterols B (