✦ LIBER ✦

Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability

✍ Scribed by Sungwoon Choi; Heather Keys; Richard J. Staples; Junying Yuan; Alexei Degterev; Gregory D. Cuny

Book ID: 116318708
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 519 KB
Volume: 22
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2012.06.098

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Specificity of substrate and inhibitor p

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

✍ Ono, S.; Hatanaka, T.; Hotta, H.; Satoh, T.; Gonzalez, F. J.; Tsutsui, M. 📂 Article 📅 1996 🏛 Informa plc 🌐 English ⚖ 904 KB

Optimal formulation of an angiogenesis i

Optimal formulation of an angiogenesis inhibitor, TNP-470, for arterial injection determined by in vitro drug release and stability, and in vivo antitumor activity

✍ Shigeo Yanai; Hiroaki Okada; Kazuhiro Saito; Yuji Kuge; Yasuaki Ogawa; Hajime To 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 663 KB

A new method for identification of in vi

A new method for identification of in vitro metabolites of 2,3,7,8-TCDD with rat liver microsomes by using liquid chromatography-mass spectrometry

✍ Wang, Chunyan; Tang, Zhi; Zhang, Yanling; Liang, Yan; Song, Fengrui; Cai, Zongwe 📂 Article 📅 2013 🏛 The Royal Society of Chemistry 🌐 English ⚖ 446 KB

In Vitro Biotransformation of 3,4-Dihydr

In Vitro Biotransformation of 3,4-Dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1( 2H )-Benzopyran (CR-6), a Potent Lipid Peroxidation Inhibitor and Nitric Oxide Scavenger, in Rat Liver Microsomes

✍ Yenes, Susana; Commandeur, Jan N. M.; Vermeulen, Nico P. E.; Messeguer, Angel 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 278 KB

In vitro metabolism of FK-506 in rat, ra

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

✍ Styliani H. Vincent; Bindhu V. Karanam; Susan K. Painter; Shuet-Hing L. Chiu 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 798 KB