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Optimization of the hygromycin B resistance-conferring gene as a dominant selectable marker in mammalian cells

✍ Scribed by Giordano, Thomas J.; McAllister, William T.


Book ID
122033065
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
359 KB
Volume
88
Category
Article
ISSN
0378-1119

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Recent demonstrations of loss of heterozygosity in a wide variety o f human cancers suggest that large multilocus genetic deletions (presumably including tumor suppressor genes) constitute a major class of genetic alteration in human carcinogenesis. Here we show that a bifunctional fusion gene (Hytk