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Optimization of the cellular import of functionally active SH2-domain-interacting phosphopeptides

✍ Scribed by Á. Kertész; G. Váradi; G. K. Tóth; R. Fajka-Boja; É. Monostori; G. Sármay

Book ID
105758462
Publisher
Springer
Year
2006
Tongue
English
Weight
515 KB
Volume
63
Category
Article
ISSN
1420-682X

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✍ Kornelia Hampel; Ina Kaufhold; Martin Zacharias; Frank D. Böhmer; Diana Imhof 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 424 KB 👁 1 views

## Abstract Src homology 2 (SH2)‐domain‐mediated interactions with phosphotyrosine (pY)‐containing ligands are critical for the regulation of SHP‐1 phosphatase activity. Peptides based on a binding site from receptor tyrosine kinase Ros (EGLN‐pY2267‐MVL, 1) have recently been shown to bind to the S