Optimization of the Biological Activity of Combinatorial Compound Libraries by a Genetic Algorithm
โ Scribed by Dr. Lutz Weber; Dr. Sabine Wallbaum; Dr. Clemens Broger; Dr. Klaus Gubernator
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 403 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The major problem associated with principal component regression (PCR), especially in QSAR studies, is that this model extracts the eigenvectors solely from the matrix of predictor variables and therefore they might not have an essentially good relationship with the predicted variable.
For many optimum design problems, the objectiยฎe function is the result of a complex numerical code and may not be differentiable and explicit. The first aim is to propose a way of solยฎing such complexity on an example problem. A noยฎel and global strategy inยฎolยฎing artificial neural networks and a ge
We have reported the characterization of transitions be-ลฝ . tween the coplanar waveguide CPW inputroutput terminals and the microstrip traveling-wave electrode of polymer electrode-optic modulators. Results of RF loss measurements of the microstrip electrode of each candidate taper were reported alo
A regional genetic algorithm (R-GA) is used for the discrete optimal design of truss structures. The chromosomes are selected from a sub-region centred on the continuous optimum. This approach replaces genetic rebirth as previously proposed by other authors, thereby signiรฟcantly reducing computation
## Abstract The aim of this work is to compare the performances of two wellโknown methods, Minimum Principle and Genetic Algorithm, in the optimization of the methyl methacrylate polymerization process in solution. In order to select a kinetic model for this process, the published kinetic models we