Optimization of selectivity by tuning column temperatures for series-coupled capilary columns in dual-oven gas chromatographic systems

✍ Scribed by D. Repka; J. Krupčik; E. Benická; P.A. Leclercq; J.A. Rijks

• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 508 KB
• Volume: 463
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)84479-4

✦ Synopsis

A method has been developed and evaluated for optimization of the selectivity of series-coupled capillary columns in a twin-oven gas chromatographic system in the shortest possible analysis time. The temperatures of either one or both columns were varied independently (partial optimization) or simultaneously (overall optimization), in order to separate the maximum number of sample components. The method is based upon computer-aided calculation of Kovats indices of the coupled columns by means of second and third order (polynomial)functions of the temperatures of the individual columns. The applicability and limitations of the method are discussed and illustrated with the separations of a synthetic hydrocarbon mixture of 33 components.